The Big Five Marathon, South Africa

Who: 250 runners

When: June 20, 2015

Why it's unique: You're running in the wilderness of the Entabeni Game Reserve in South Africa's Limpopo province in Waterberg on a tricky footing that morphs from deep sand to streams of clunky rocks. When not navigating the treacherous tread, you're on safari; this part of South Africa, west of Kruger and next to Botswana, is known for easy sightings of the big five game animals: lions, leopards, elephants, buffalos, and rhinoceros. [big-five-marathon.com]