Cancer screening has become a very hot topic of debate. For men, the question of whether or not to get screened for prostate cancer is the big one. Even the American Cancer Society only goes so far as advising a discussion about screening at age 50 because there is actually a lot of risk associated with the prostate-specific antigen (PSA) test. "If you look hard enough, you'll find cancer lesions," says Colditz. In fact, around 13 percent of men who get a PSA end up with a false alarm and over 10 years, 20 percent will be biopsied. A third of men who are biopsied experience problems afterward and no one has definitively proved that PSA's save lives. The lesson with screening is talk to your doctor in-depth about it first.