For some, there is a big downside to orgasm. Post-orgasmic illness syndrome (POIS) is a rare disorder where people feel ill after orgasm. Symptoms can include intestinal discomfort, headache, and general malaise. "Just having orgasms makes them feel sick for days after and nobody really knows what the mechanism is," says Komisaruk, who has just secured a grant from the National Organization of Rare Diseases to study this affliction. No one knows how common POIS is, but Komisaruk is currently working with a couple dozen men with the symptoms to shed further light on this disorder.
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