Lou Malnati's Pizzeria, Chicago, IL.
A typical visit to the Windy City includes the big buildings, the museums, and maybe a boat ride around Lake Michigan. Oh yeah, and you have to try the city's famous deep dish pizza, that's sort of a must. Since 1971, nobody has made a better Chicago-style pie (literally, it's a pie) than Lou Malnati's.
The thing that sets Malnati's above all the other spots that claim to make the city's best deep dish is the crust. You get that buttery flavor in every bite no matter which pie you get, and combined with the lean sausage and vine-ripened tomato sauce, you'll instantly understand why Chicago earned its own pizza style.
It might put you out after once slice, but there are very few pizza experiences like it anywhere in America.