Avoid Painkillers If You Can
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If you have time for it, sleep is one of the healers, says Murray says. If painkillers such as aspirin or ibuprofen will help rid you of your pounding headache and let you sleep, then take them. Just stay away from acetaminophen, which can damage the liver if it interacts with alcohol. Also, make sure to never mix painkillers with heavy drinking – they can hurt your stomach (ibuprofen and aspirin) or liver (acetaminophen).