Dr. Modena says that the verdict is still out on whether allergy shots work long-term for pet allergies. But Dr. Sublett says he's seen good outcomes from shots and often recommends them for people committed to keeping their pet. There are three types of shots, one which slowly helps you build up a tolerance over a long period of time, one that works over a slightly shorter period of time, and one that ramps up your tolerance over just a few days. Which approach is right for you is something you'll need to discuss with your allergist, but he explains it like this: "Think of it like a reset; with shots you're basically dialing down your reaction to an animal."
Also, Sublett adds one caveat: Don't start a shot regimen before you've actually been diagnosed with a true pet allergy. "You could actually have a dust mite or mold allergy. The key is to check with an allergist if you're suspicious that you're allergic to your pet."