Omega-3s may be the single best supplement you can take on a regular basis. They help reduce levels of blood fats that can lead to heart disease, and they counter omega-6s, which can cause inflammation in high amounts. Most of us eat more omega-6s than we should because they're found in most processed foods. It's key to have enough omega-3s to keep the 6s in check.
Some of the most effective supplements are foods we don't normally eat that have strong medicinal properties. Whenever I can get a nutrient or health benefit from a root, an herb, or a functional food instead of a pill, the effects will be stronger.