21c Museum Hotel, Louisville

Open since 2006, the contemporary 21c Museum Hotel spearheaded by Louisville art collectors Steve Wilson and Laura Lee Brown would be equally at home in Brooklyn or Berlin as it is in the less-expected locale of a revitalized downtown Louisville neighborhood. Edgy art galleries housed here (free admission) are open 24/7, like the hotel, and docents who double as hotel staff lead guided tours on Fridays and Saturdays. Original exposed brick walls in many of the loft-like guestrooms hint at the building’s former life as a warehouse and taut white linens, high ceilings, and original art make the minimalist look warm. The hotel's restaurant, Proof on Main, was opened by a Nobu alum and is one of the town's hottest tables. [Rooms from $270; 21cmuseumhotels.com]