"Men have thicker skin than women, so to soften rough hands you need something that's going to penetrate," Frank explains. "Plain old moisturizer won't work." What does: Aquaphor Advanced Therapy Healing Ointment ($7, drugstore.com). "Ideally, guys should rub Aquaphor on their hands before bed, put on a pair of gloves and let it soak in while they sleep," Frank says. What's that? Not a gloves-to-bed guy? You can also apply before heading to the garage to work on the car or before doing yard work — or any other place where wearing gloves feels a bit more natural.