8 Supplements That Actually Work

Bummed out? Try St. John’s wort
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Bummed out? Try St. John’s wort

If you’re consistently feeling down and aren’t hip on pharmaceutical antidepressants, check out St. John’s wort, probably the best-studied natural remedy for depressive symptoms. While it’s not clear exactly how, this plant affects serotonin and dopamine, the brain’s feel-good neurotransmitters. Several human trials have shown that it works to boost mood, potentially as well as SSRI drugs like Paxil or Prozac. Caveat: St. John’s wort interacts negatively with SSRIs, anticoagulants, and other medications, as well as some other supplements. So before trying it, definitely discuss it with your doctor and a pharmacist, who should be well-schooled in supplement-drug interactions.

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