Get the Right Seat
A window seat is key. Rows in the back will be less populated than those up front. Seatguru.com can tell you what seats to avoid — non-recliners and rows that get cold.
Pack an eye mask, a travel pillow, and earplugs or noise-canceling headphones. Planes get cold, so bring an extra layer and a pair of wool socks to keep your feet warm and stink-free.
Hack Your Body Clock
If you'll be crossing multiple time zones, go to jetlagrooster.com Enter your flight data and you get a sleep schedule to help you begin acclimating to the new time zone days before you leave.
While dropping your bags at the hotel is a good idea, a nap is not. To adjust to the new time zone, seek out natural light, then power through the day — until the locals go to bed.