7. No. 15 Hampton Over No. 2 Iowa State (2001)
In 2001, Hampton became another one of those “what-state-are-they-from?” schools to beat one of the tournament favorites in the first round. The 15-seeded Pirates got the win in dramatic fashion, going on a 14-2 run over the last eight minutes, which finished with a game winning shot by Hampton’s Tarvis Williams with 6.9 seconds to go. The basket gave Hampton a 58-57 lead, which ended up being the final score after a missed lay up by Iowa State’s Jamaal Tinsley with just over a second to play. Like all other 15-seeds to survive the first round, they didn’t win another game, but the damage was done.
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