46. Hilton Head, SC
Why Hilton Head: An affordable domestic escape for east-coast travelers, Hilton Head Island offers temperate weather all year—but shoulder season is especially nice for avoiding high-season crowds. In April, the RBC Heritage Presented by Boeing—South Carolina’s only PGA golf tournament—takes place at the famed Harbour Town Golf Links.
Where to stay: Health-oriented travelers will love Hilton Head Health, where exercise classes—from early morning hikes to bootcamp and yoga—are held just steps from the ocean (or even on it, if you sign up for a paddle-boarding excursion). TRUE Restaurant serves up low-calorie meals that don’t skimp on flavor, and Indigo Spa offers custom organic facials and muscle-soothing massages.
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